Utah State University
 

Utah State

THE SIGHT of a bug would fill his bright eyes with astonishment. The whole world was a wonderment then, a stimulator of speech. But at 18 months of age, after the fourth and largest in a series of diphtheria-pertussis-tetanus vaccinations, their babbling boy, Ian, fell into a deep, prolonged slumber from which he never fully awakened. In almost every way imaginable he was a different boy. His desire to speak vanished.. Instead of sounding out the consonants in a new word, he shrieked in terror at the slightest deviation in his inviolate schedule. His bedroom became his self-imposed fortress, the constant droning of videotaped cartoons his only companion. Even a hug from Mom tormented him.

He was tormented - by the enlarged white matter, elevated serotonin levels and impaired limbic system in his brain. Medical doctors offered no hope of a treatment or cure.

USU neuroimmunologist Vijendra Singh has been studying autism for well over 15 years. Having witnessed firsthand the emotional and financial toll on families, he is deeply disturbed by the statistics. Autism is the fastest growing developmental disability in children, he says. In 1993, only four or five children in 10,000 were afflicted. Ten years later, five times that many children were being diagnosed. In Utah alone autism rates have jumped 750 percent in the past decade. No country is immune - the numbers for Mexico, India and China are as alarming as in Canada, Europe and Australia.


Fifteen years ago, Singh began investigating a novel idea - that the immune system itself plays a central role in autism

Fifteen years ago, Singh began investigating a novel idea - that the immune system itself played a central role. Medical scientists dismissed this line of thinking as a waste of time. Today they take his research seriously. In testimony before Congress, and presentations before the National Academy of Science, Institute of Medicine (IOM) and Centers for Disease Control and Prevention (CDC), Singh has reported his findings: three quarters of autistic children suffer from an autoimmune disorder. Most of these children displayed none of the classic symptoms of autism until shortly after receiving a measles-mumps-rubella shot. Singh recommended testing their immunity first. "Doctors give five to ten shots at one time to a child. Six months later they administer another battery of vaccinations. If you don't have a healthy immune system, then you might be unable to make proper antibodies to counter the virus." Immunity testing would not only protect vulnerable children from brain damage but detect allergies, which are now found in half of all children.

But at $100 per test, the tightly funded CDC shelved the proposal. It was too expensive and impractical - for the time being at least. Singh's initial response: "Well, yes, everything costs money but as public health workers aren't we supposed to take care of children in the community? Shouldn't we be practicing preventative medicine? Hundreds of new vaccines are in the pipeline. The problem is only going to get worse."

Singh does not oppose vaccines. Aggressive childhood immunization programs in this country help combat contagious diseases due to viruses and bacteria. "But these vaccines can also cause adverse reactions in a small but significant portion of the population," he says.
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